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 - Northwestern Memorial Hospital - Chicago


Localized scleroderma is an autoimmune disease that affects the skin in limited areas and the musculoskeletal system. Systemic sclerosis causes more widespread skin changes and may be associated with internal organ damage, arthritis, gastrointestinal symptoms, and cold-induced Raynaud’s phenomenon.

Internet Resources

Medlineplus: Scleroderma
Developed and maintained by the National Library of Medicine for consumers, this portal site offers access to a wide array of resources concerning scleroderma.

Scleroderma: Handout on Health
Developed by the National Institute of Arthritis and Musculoskelatal and Skin Diseases to describe the different forms of scleroderma, this page provides information on symptoms, diagnosis, treatment, and current research.

The website of the American College of Rheumatology (ACR) offers information covering the more than 100 types of arthritis and related disabling and sometimes fatal disorders of the joints, muscles, and bones.

Northwestern Scleroderma Program
The Northwestern Scleroderma Program is committed to providing state of the art patient care, conducting research toward a cure, and increasing awareness about scleroderma.


  • Scleroderma book: a guide for patients and families. Mayes M. 2005
  • First year – scleroderma: a sourcebook for the newly diagnosed. Gottesman K. 2004


The Health Learning Center has a large model of skin. Ask Service Desk staff for assistance.
To gain a better understanding of how the immune system works, visit one of the following sites:

Immune System and Disorders

Understanding the Immune System from the National Cancer Institute


  • “Pathogenesis and therapeutic approaches for improved topical treatment in localized scleroderma and systemic sclerosis.” Badea I. Taylor M. Rosenberg A. Foldvari M. Rheumatology. March 2009. 48(3):213-21.
  • “Systemic sclerosis/scleroderma: a treatable multisystem disease.” Hinchcliff M. Varga J. American Family Physician. October 2008. 78(8):961-968.
  • “New Therapeutic Strategies in the Management of Systemic Sclerosis.” Expert Opinion on Pharmacotherapy. Allanore Y. April 2007. 8(5):607–615.
  • “Systemic and Localized Scleroderma.” Clinics in Dermatology. Chung L. September–October 2006. 24(5):374–392.


Scleroderma Foundation
12 Kent Way #101 Byfield, MA 01922
800-722-Hope (722-4673)

Contact Us

For more information, please contact the  Health Learning Center  at 312-926-5465 or HLC@nmh.org.

Last UpdateDecember 2, 2011