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 - Northwestern Memorial Hospital - Chicago

Early Use of Sanvar® to Control Acute Variceal Bleeding

The Early Use of Sanvar® with Endoscopic Treatment for the Control of Acute Variceal Bleeding Due to Portal Hypertension

The primary purpose of this study is to determine the efficacy of the early administration of Sanvar(r) (vapreotide) in association with endoscopic treatment for the control of bleeding at 5 days, i.e. control of initial bleeding and prevention of early re-bleeding, plus survival. These results will be evaluated for clinical significance in light of the efficacy results achieved in the vapreotide pivotal trial and the results reported in the available literature on octreotide.

The secondary purpose of this study is to assess the following:

  • The effect of drug administration before endoscopy assessed by the endoscopic facilitation and control of bleeding at endoscopy

  • Control of bleeding 6 hours after infusion of the study drug

  • Control of bleeding by time periods and by Child Pugh class

  • Number of blood units administered during the 5 days of drug infusion

  • Safety of treatment

Sponsor:

Debiovision

Principle Investigator:

Andres T. Blei, MD

Cost:

None

IRB Project Number:

0126-027

Contact:

Jeanne Gottstein
312-908-5902

Last UpdateMarch 25, 2011
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