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 - Northwestern Memorial Hospital - Chicago

Liver Transplantation Clinical Trials

Acute/Chronic Liver Failure

Multi-Center Group to Study Acute Liver Failure (ALF). Long-term Outcomes of ALF

The present study will allow an in-depth analysis of cases of acute liver failure from 40 centers around the United States in the ALF Study Group (ALFSG).  Learn more . . . 

Probiotics: A New Approach To Correct Intestinal Permability Of Patients With Cirrhosis Awaiting Liver Transplant

To determine the effect of 30 day administration of probiotics on intestinal permeability (lactulose/mannitol test) in patients with cirrhosis and ascites. Learn more . . . 

The Early Use of Sanvar® with Endoscopic Treatment for the Control of Acute Variceal Bleeding Due to Portal Hypertension

To determine the efficacy of the early administration of Sanvar(r) (vapreotide) in association with endoscopic treatment for the control of bleeding at 5 days, i.e. control of initial bleeding and prevention of early re-bleeding, plus survival. Learn more . . . 

Long-Term Follow-up of Subjects in a Phase 2 or 3 Clinical Trial in which SCH 503034 was Administered for the Treatment of Chronic Hepatitis C (P05063)

To monitor for possible mutation variants in the body in patients previously treated with SCH 503034, a protease inhibitor. Learn more . . . 
 


Hepatitis B

There are no Hepatitis B clinical trials at this time.


Hepatitis C

 A Phase 3, Randomized, Multi-Center Study to Evaluate the Efficacy and Safety of Albumin Interferon Alfa-2b (alb-IFN) in Combination with Ribavirin Compared with Peginterferon Alfa-2a (PEGASYS® or PEG-IFNα2a) in Combination with Ribavirin in Interferon Alfa Naïve Subjects with Chronic Hepatitis C Genotype 1

The purpose of this study is to evaluate the safety and efficacy of alb-IFN given with Ribavirin compared to the standard of care  IFN-alfa 2a/2b plus ribavirin. Learn more . . . 

Comparison of Weight-based Doses of Taribavirin Combined With Peginterferon Alfa 2b Versus Ribavirin Combined With Peginterferon Alfa-2b in Therapy-naïve Patients With Chronic Hepatitis C Virus Genotype 1 Infection

The purpose of this study is to evaluate the safety and efficacy of Taribavirin when given with IFN-alfa 2b vs. the standard of care IFN-alfa 2b plus ribavirin. Learn more . . . 

A Safety and Efficacy Study of SCH 503034 in Previously Untreated Subjects With Chronic Hepatitis C Infected With Genotype 1

The purpose of this study is to evaluate the safety and efficacy of a protease inhibitor given with IFN-alfa 2b and ribavirin. Learn more . . . 


Nonalcoholic Steatohepatits (NASH)

The Effect of Pentoxifylline on Nonalcoholic Steatohepatitis (NASH)

This is an investigational study looking at subjects who have been diagnosed with nonalcoholic steatohepatitis (NASH) or 'fatty liver disease'. The purpose of this study is to explore the potential benefit of the medication, pentoxifylline, for the treatment of NASH. Learn more . . . 

The Assessment of Variability in Histology and Gene Expression in Bariatric Surgery Patients

The purpose of this study is to examine variability of hepatic histology as well as expression of key metabolic genes in NAFLD/NASH patients undergoing bariatric surgery. Learn more . . . 


Liver Transplant Trials

A2ALL LADR Protocol: Pre-Transplant Treatment to Prevent Recurrence of Hepatitis C After Living Donor Liver Transplantation (sub-study to main A2ALL study)

The purpose of this study is to learn if pre-liver transplant treatment using peginterferon plus ribavirin will clear HCV RNA from the blood in HCV-infected recipients, and reduce the risk of recurrent HCV and re-infection of the new liver with hepatitis following liver transplant. Learn more. . .

Genes Related to HCC Progression on Living Donor and Deceased Donor Transplant Recipients

This study will explore the hypothesis that establishment of a molecular-based method for the classification of Hepatitis C/liver cancer at diagnosis will permit the detection of distinct subgroups of liver cancer patients with different prognoses. Learn more. . .

A2ALL Human Liver Explants for HIF-1 Alpha Analysis/Comparison

The primary study objective is to compare levels of HIF-1α (Hypoxia Inducing Factor 1-alpha) expression in HCC tumor explants. Learn more. . . 

PROTECT. Pegylated Interferon alfa-2b and Ribavirin After Orthotopic Liver Transplantation: Efficacy and Safety in Hepatitis C Recurrence Therapy

This study will determine the sustained virologic response (SVR) at the 24-week follow up after treatment with PEG-IFN -2b and Ribavirin in post-orthotopic liver transplant. Learn more. . . 

Immune Tolerance and Alloreactivity in Liver Transplant Recipients on Different Monotherapy Immunosuppressive Agents

This study is a pilot investigation comparing immune tolerance and alloreactivity profiles in Liver transplant recipients on Monotherapy IS or being converted to rapamycin or MMF Monotherapy. Learn more. . . 

Liver Transplant Protocol for HIV-infected Recipients

The primary aim of this study is to evaluate the safety and efficacy of solid organ transplantation in people with HIV disease. Learn more. . . 

Last UpdateFebruary 8, 2011
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