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 - Northwestern Memorial Hospital - Chicago

Genes Related to HCC Progression Liver Transplant Recipients

Genes Related to HCC Progression in Living Donor and Deceased Donor Transplant Recipients


The purpose of this study is to explore the hypothesis that establishment of a molecular-based method for the classification of Hepatitis C/liver cancer at diagnosis will permit the detection of distinct subgroups of liver cancer patients with different prognoses, allowing greater accuracy in selection of patients for treatment cure with transplantation.

This study hopes to identify the genes involved in the development of liver cancer in patients with Hepatitis C cirrhosis. In addition, we plan to examine the genes implicated in tumor progression in patients with Hepatitis C/liver cancer while waiting for transplantation. Finally, this study looks to determine the potential role of the genetic markers in predicting post-transplantation outcomes in Hepatitis C-infected patients with liver cancer.

Inclusion Criteria:

All patients with a diagnosis of hepatocellular carcinoma from August 1, 1994 through October 31, 2005. This will encompass the time frame in which the liver transplant program was started through its current day.



Principle Investigator:

Laura Kulik, MD



IRB Project Number:



Patrice Al-Saden, RN

Last UpdateMarch 25, 2011